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KMID : 1123920120260020147
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 2 p.147 ~ p.154
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Effects of Hwanggeum-tang Water Extract on the Expression of Pro-inflammatory Responses Elicited by Advanced Glycation End Products in THP-1 Cells
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Jeong Sang-Hun
Lee Kwang-Gyu
Lee Chang-Hyun
Lee Sang-Ryong
Kim Jae-Eun
Ha Ki-Tae
Shin Sang-Woo
Jeong Han-Sol
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Abstract
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Hwanggeum-tang (HGT) was recorded in Dongeuibogam as being able to treat Sogal whose concept had been applied to Diabetes Mellitus (DM). Advanced glycation end products (AGEs) play important roles in the development of diabetic complications such as atherosclerosis by eliciting inflammatory responses. In this study, we examined the suppressive effects of HGT against inflammation elicited by AGEs. AGEs treatment increased the expression of pro-inflammatory cytokine gene TNF-α; chemokines MCP-1, IP-10; pro-inflammatory cyclooxygenase COX-2 on the THP-1 cells. HGT had suppressed the expression of pro-inflammatory genes and protein levels in AGE-treated THP-1 cells. HGT had also decreased intracellular ROS production stimulated by AGEs. These results suggest that HGT has beneficial effects for the improvement diabetic vascular complication through suppressing inflammatory responses elicited by AGEs.
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KEYWORD
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Advanced glycation end products, TNF-α, MCP-1, COX-2
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